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Overall, the effects on weight loss of synthetic ephedrine plus caffeine and ephedra plus herbs containing caffeine were equivalent: weight loss of approximately 2 pounds/month more than was associated with placebo for up to 4 or 6 months of use. No studies assessed the long-term effects on weight loss; the longest published follow-up was 6 months. Jun 29, 2020 Nov 12, 2012 By comparison, a diet with a provision of 3300 kJ/d achieves a mean weight loss of ≈1.5–2.5 kg/wk, and a more moderate energy restriction to 5000 kJ/d results in a weight loss of 0.5–0.6 kg/wk . Therefore, it seems that the observed effect with chromium picolinate is, although statistically significant, not clinically meaningful.
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